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1

Prediction of Hepatic Metabolic Clearance Based on Interspecies Allometric Scaling Techniques andIn Vitro-In VivoCorrelations

Dr Thierry Lavé, Philippe Coassolo, Bruno Reigner

Journal:

Clinical Pharmacokinetics

Année:

1999

Langue:

english

Fichier:

PDF, 277 KB

english, 1999

2

Régulation épigénétique de l’expression génique dans le mélanome malin

Laurette, Patrick, Koludrovic, Dana, Coassolo, Sebastien, Davidson, Irwin

Journal:

Biologie Aujourd hui

Année:

2016

Fichier:

PDF, 2.70 MB

2016

3

Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry

C. Aubert, J. P. Sommadossi, Ph. Coassolo, J. P. Cano, J. P. Rigault

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Année:

1982

Langue:

english

Fichier:

PDF, 338 KB

english, 1982

4

Determination of midazolam and its major hydroxy metabolite in plasma by gas liquid chromatography. Application to a pharmacokinetic study

P. Coassolo, C. Aubert, Y. Sumirtapura, J. P. Cano

Journal:

Journal of Separation Science

Année:

1982

Langue:

english

Fichier:

PDF, 472 KB

english, 1982

5

Determination of flurazepam and its hydroxyethyl and dealkyl metabolites by some packed and capillary ECD-GLC methods: Application to pharmacokinetic studies

Ph. Coassolo, C. Aubert, J. P. Cano

Journal:

Journal of Separation Science

Année:

1984

Langue:

english

Fichier:

PDF, 523 KB

english, 1984

6

An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery

Neil Parrott, Nicolas Paquereau, Philippe Coassolo, Thierry Lavé

Journal:

Journal of Pharmaceutical Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 494 KB

english, 2005

7

Comparison of an iterative microcalorimetric method and dialysis equilibrium for calculating thermodynamic parameters of a binding protein which presents a weak affinity for its substrate

P. Coassolo, M. Sarrazin, J.C. Sari

Journal:

Analytical Biochemistry

Année:

1980

Langue:

english

Fichier:

PDF, 464 KB

english, 1980

8

Rapid determination of the metabolic pool of ethyl loflazepate in biological fluids by capillary gas chromatography

B.B. Ba, H. Bun, P. Coassolo, J.P. Cano

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

1986

Langue:

english

Fichier:

PDF, 232 KB

english, 1986

9

Capillary gas chromatographic-mass spectrometric method for the identification and quantification of some benzodiazepines and their unconjugated metabolites in plasma

Christine Drouet-Coassolo, Claude Aubert, Philippe Coassolo, Jean-Paul Cano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1989

Langue:

english

Fichier:

PDF, 756 KB

english, 1989

10

Simultaneous assay of triazolam and its main hydroxy metabolite in plasma and urine by capillary gas chromatography

Ph. Coassolo, C. Aubert, J.P. Cano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1983

Langue:

english

Fichier:

PDF, 626 KB

english, 1983

11

Determination of Clobazam, n-desmethylclobazam and their hydroxy metabolites in plasma and urine by high-performance liquid chromatography

Jean-Luc Tomasini, Hot Bun, Philippe Coassolo, Claude Aubert, Jean-Paul Cano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1985

Langue:

english

Fichier:

PDF, 560 KB

english, 1985

12

Determination of 7-amino-flunitrazepam (Ro 20-1815) and 7-amino-desmethylflunitrazepam (Ro 5-4650) in plasma by high-performance liquid chromatography and fluorescence detection

Y.C. Sumirtapura, C. Aubert, Ph. Coassolo, J.P. Cano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1982

Langue:

english

Fichier:

PDF, 544 KB

english, 1982

13

Should all pregnant diabetic women undergo a fetal echocardiography? A cost-effectiveness analysis comparing four screening strategies

Anthony O. Odibo, Kara M. Coassolo, David M. Stamilio, Serdar H. Ural, George A. Macones

Journal:

Prenatal Diagnosis

Année:

2006

Langue:

english

Fichier:

PDF, 90 KB

english, 2006

14

Modification of human serum albumin binding of methotrexate by folinic acid and certain drugs used in cancer chemotherapy

P. Coassolo, M. Valentin, M. Bourdeaux, C. Briand

Journal:

European Journal of Clinical Pharmacology

Année:

1980

Langue:

english

Fichier:

PDF, 495 KB

english, 1980

15

Relationships betweenin vitroandin vivobiotransformation of drugs in humans and animals: pharmaco-toxicological consequences

G. Sousa, N. Florence, B. Vallès, P. Coassolo, R. Rahmani

Journal:

Cell Biology and Toxicology

Année:

1995

Langue:

english

Fichier:

PDF, 502 KB

english, 1995

16

Comparison of the stability of some major cytochrome P450 and conjugation reactions in rat, dog and human hepatocyte monolayers

Genevieve Ubeaud, Claus-Ditter Schiller, Fabrice Hurbin, Daniel Jaeck, Philippe Coassolo

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Année:

2001

Langue:

english

Fichier:

PDF, 1.48 MB

english, 2001

17

Plasma determination of 3-methylclonazepam by capillary gas chromatography

Philippe Coassolo, Claude Aubert, Jean-Paul Cano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1985

Langue:

english

Fichier:

PDF, 504 KB

english, 1985

18

Determination of the aromatic retinoids (etretin and isoetretin) in biological fluids by high-performance liquid chromatography

Nouha Rajab Al-Mallah, Hot Bun, Philippe Coassolo, Claude Aubert, Jean Paul Cano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1987

Langue:

english

Fichier:

PDF, 518 KB

english, 1987

19

Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists

S. Röver, D.R. Adams, A. Bénardeau, J.M. Bentley, M.J. Bickerdike, A. Bourson, I.A. Cliffe, P. Coassolo, J.E.P. Davidson, C.T. Dourish, P. Hebeisen, G.A. Kennett, A.R. Knight, C.S. Malcolm, P. Mattei,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 179 KB

english, 2005

20

Plasma quantification of quazepam and its 2-oxo and N-desmethyl metabolites by capillary gas chromatography

Hot Bun, Philippe Coassolo, Boubakar Ba, Claude Aubert, Jean-Paul Cano

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1986

Langue:

english

Fichier:

PDF, 495 KB

english, 1986

21

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: Application to 10 extensively metabolized drugs

Th. Lave, S. Dupin, C. Schmitt, R. C. Chou, D. Jaeck, Ph. Coassolo

Journal:

Journal of Pharmaceutical Sciences

Année:

1997

Langue:

english

Fichier:

PDF, 478 KB

english, 1997

22

Commentry on “integration of in vitro data and brain weight in allometric scaling to predict clearance in humans: Some suggestions”1

T. Lave, P. Coassolo

Journal:

Journal of Pharmaceutical Sciences

Année:

1998

Langue:

english

Fichier:

PDF, 20 KB

english, 1998

23

Strain difference (WKY, SPRD) in the hepatic antioxidant status in rat and effect of hypertension (SHR, DOCA). Ex vivo and in vitro data

Delphine Binda, Laurence Nicod, Catherine Viollon-Abadie, Sandrine Rodriguez, Alain Berthalot, Philippe Coassolo, Lysiane Richert

Journal:

Molecular and Cellular Biochemistry

Année:

2001

Langue:

english

Fichier:

PDF, 153 KB

english, 2001

24

The Use of Human Hepatocytes to Select Compounds Based on Their Expected Hepatic Extraction Ratios in Humans

Th. Lavé, S. Dupin, C. Schmitt, B. Valles, G. Ubeaud, R. C. Chou, D. Jaeck, Ph. Coassolo

Journal:

Pharmaceutical Research

Année:

1997

Fichier:

PDF, 360 KB

1997

25

Interspecies Scaling of Bosentan, A New Endothelin Receptor Antagonist and Integration ofin VitroData into Allometric Scaling

Thierry Lave, Philippe Coassolo, Geneviève Ubeaud, Roger Brandt, Christophe Schmitt, Sylvie Dupin, Daniel Jaeck, Ruby C. Chou

Journal:

Pharmaceutical Research

Année:

1996

Fichier:

PDF, 756 KB

1996

26

Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations

Nadège Blanchard, Nicola J. Hewitt, Paul Silber, Hannah Jones, Philippe Coassolo, Thierry Lave

Journal:

Journal of Pharmacy and Pharmacology

Année:

2006

Langue:

english

Fichier:

PDF, 198 KB

english, 2006

27

In vivo and in vitro kinetics of mofarotene in mouse, rat, dog and man

B. Vallès, B. Ba, R. Wyss, B. Reigner, Ph Coassolo

Journal:

European Journal of Drug Metabolism and Pharmacokinetics

Année:

1995

Langue:

english

Fichier:

PDF, 493 KB

english, 1995

28

Is fetal gender associated with adverse perinatal outcome in intrauterine growth restriction (IUGR)?

Joanne N. Quiñones, David M. Stamilio, Kara M. Coassolo, George A. Macones, Anthony O. Odibo

Journal:

American Journal of Obstetrics and Gynecology

Année:

2005

Langue:

english

Fichier:

PDF, 131 KB

english, 2005

29

Neonatal hypoglycemia in term, nondiabetic pregnancies

Amy M. DePuy, Kara M. Coassolo, Dara A. Som, John C. Smulian

Journal:

American Journal of Obstetrics and Gynecology

Année:

2009

Langue:

english

Fichier:

PDF, 254 KB

english, 2009

30

6: A randomized controlled trial of wound complication rates of subcuticular suture vs staples for skin closure at cesarean delivery

Suzanne Basha, Meredith Rochon, Joanne Quinones, Kara Coassolo, Orion Rust, John Smulian

Journal:

American Journal of Obstetrics and Gynecology

Année:

2009

Langue:

english

Fichier:

PDF, 92 KB

english, 2009

31

159: Patient satisfaction with subcuticular suture vs. staple closure at cesarean delivery: a randomized controlled trial

Meredith Rochon, Suzanne Basha, Joanne Quinones, Kara Coassolo, Orion Rust, John Smulian

Journal:

American Journal of Obstetrics and Gynecology

Année:

2009

Langue:

english

Fichier:

PDF, 202 KB

english, 2009

32

Randomized controlled trial of wound complication rates of subcuticular suture vs staples for skin closure at cesarean delivery

Suzanne L. Basha, Meredith L. Rochon, Joanne N. Quiñones, Kara M. Coassolo, Orion A. Rust, John C. Smulian

Journal:

American Journal of Obstetrics and Gynecology

Année:

2010

Langue:

english

Fichier:

PDF, 271 KB

english, 2010

33

Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

Nadège Blanchard, Lysiane Richert, Brigitte Notter, Frederic Delobel, Pascale David, Philippe Coassolo, Thierry Lavé

Journal:

European Journal of Pharmaceutical Sciences

Année:

2004

Langue:

english

Fichier:

PDF, 180 KB

english, 2004

34

Piperidine renin inhibitors: from leads to drug candidates

H.P. Märki, A. Binggeli, B. Bittner, V. Bohner-Lang, V. Breu, D. Bur, Ph. Coassolo, J.P. Clozel, A. D'Arcy, H. Doebeli, W. Fischli1, Ch. Funk, J. Foricher, T. Giller, F. Grüninger, A. Guenzi, R. Gülle

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 221 KB

english, 2001

35

Estimation of flavin-containing monooxygenase activity in intact hepatocyte monolayers of rat, hamster, rabbit, dog and human by using N-oxidation of benzydamine

Geneviève Ubeaud, Claus-Ditter Schiller, Fabrice Hurbin, Daniel Jaeck, Philippe Coassolo

Journal:

European Journal of Pharmaceutical Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 447 KB

english, 1999

36

Pharmacokinetics of flunitrazepam following single dose oral administration in liver disease patients compared with healthy volunteers

C. Drouet-Coassolo, A. Iliadis, P. Coassolo, M. Antoni, JP Cano

Journal:

Fundamental & Clinical Pharmacology

Année:

1990

Langue:

english

Fichier:

PDF, 390 KB

english, 1990

37

Microcalorimetric studies on the binding of some benzodiazepin derivatives to human serum albumin

P. Coassolo, M. Sarrazin, J.C. Sari, C. Briand

Journal:

Biochemical Pharmacology

Année:

1978

Langue:

english

Fichier:

PDF, 707 KB

english, 1978

38

Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance

Delphine Jouin, Nadège Blanchard, Eliane Alexandre, Frédéric Delobel, Pascale David-Pierson, Thierry Lavé, Daniel Jaeck, Lysiane Richert, Philippe Coassolo

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2006

Langue:

english

Fichier:

PDF, 163 KB

english, 2006

39

Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions

Catherine Abadie-Viollon, Hélène Martin, Nadège Blanchard, Dumrongsak Pekthong, Philippe Bachellier, Georges Mantion, Bruno Heyd, Frantz Schuler, Philippe Coassolo, Eliane Alexandre, Lysiane Richert

Journal:

Toxicology in Vitro

Année:

2010

Langue:

english

Fichier:

PDF, 616 KB

english, 2010

40

Cryopreservation of adult human hepatocytes obtained from resected liver biopsies

E Alexandre, C Viollon-Abadie, P David, A Gandillet, P Coassolo, B Heyd, G Mantion, P Wolf, P Bachellier, D Jaeck, L Richert

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 269 KB

english, 2002

41

Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes

L Richert, D Binda, G Hamilton, C Viollon-Abadie, E Alexandre, D Bigot-Lasserre, R Bars, P Coassolo, E LeCluyse

Journal:

Toxicology in Vitro

Année:

2002

Langue:

english

Fichier:

PDF, 858 KB

english, 2002

42

Animal Pharmacokinetics and Interspecies Scaling from Animals to Man of Lamifiban, a New Platelet Aggregation Inhibitor

THIERRY LAVE, ALPHONSE SANER, PHILIPPE COASSOLO, R. BRANDT, ANNE H. SCHMITT-HOFFMANN, RUBY C. CHOU

Journal:

Journal of Pharmacy and Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 438 KB

english, 1996

43

Prediction of Hepatic Metabolic Clearance

Jochen Zuegge, Gisbert Schneider, Philippe Coassolo, Dr Thierry Lavé

Journal:

Clinical Pharmacokinetics

Année:

2001

Langue:

english

Fichier:

PDF, 208 KB

english, 2001

44

Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

Ubeaud, G., Schmitt, C., Jaeck, D., Lave, T., Coassolo, Ph.

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 696 KB

english, 1995

45

Microcalorimetric method to determine competitive binding action of a psychotropic drug (dipotassium chlorazepate) on ?-tryptophan · human serum albumin complex

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

1978

Langue:

english

Fichier:

PDF, 546 KB

english, 1978

46

A new extrapolation method from animals to man: Application to a metabolized compound, mofarotene

Lave, T., Schmitt-Hoffmann, A.H., Coassolo, P., Valles, B., Ubeaud, G., Ba, B., Brandt, R., Chou, R.C.

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 397 KB

english, 1995

47

PLAYING FIELDS FOR LONDON.

Lave, T., Schmitt-Hoffmann, A.H., Coassolo, P., Valles, B., Ubeaud, G., Ba, B., Brandt, R., Chou, R.C.

Journal:

Année:

1890

Langue:

english

Fichier:

PDF, 189 KB

english, 1890

48

Combining in Vitro and in Vivo Pharmacokinetic Data for Prediction of Hepatic Drug Clearance in Humans by Artificial Neural Networks and Multivariate Statistical Techniques

Schneider, Gisbert, Coassolo, Philippe, Lavé, Thierry

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 60 KB

english, 1999

49

Synthesis and physical properties of liquid-crystalline polyesters derived from 4,4'-dihydroxybicyclohexyl

Coassolo, A., Foa, M., Dainelli, D., Scordamaglia, R., Barino, L., Chapoy, L. L., Rustichelli, F., Yang, B., Torquati, G.

Journal:

Année:

1991

Langue:

english

Fichier:

PDF, 2.58 MB

english, 1991

50

The Determination By Means of Capillary Gas Chromatography of the Benzodiazepines-Clobazam, Clonazepam, Diazepam, and Nitrazepam-and Their Principal Metabolites Currently Used In the Treatment of Epilepsy

Bun, H., Dechamp, C., Coassolo, Ph., Cano, J. P.

Journal:

Analytical Letters

Année:

1989

Langue:

english

Fichier:

PDF, 437 KB

english, 1989